San Francisco near 79% at home is a heavy number that leans on the assumption Brock Purdy is back and healthy, which is exactly what to verify before taking the favorite. Purdy has a long turf-toe and shoulder history, and the 49ers have leaned on Mac Jones through stretches of it. Arizona has spent recent seasons cycling through Jacoby Brissett behind an injured Kyler Murray, with receiver depth thinning at the worst times. A four-to-one price gives you almost nothing on the favorite and real leverage on the underdog if a Friday injury report reshuffles the quarterback picture on either side.
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