Seattle near 65% is priced as the road favorite despite starting Drew Lock, with Sam Darnold ruled out after a glute injury on the opening drive of Week 1. Lock managed a 13-10 win over New England in relief, and the Seahawks lean on defense and a strong receiver group with Jaxon Smith-Njigba and Cooper Kupp. Arizona is 1-0 off a road upset of the Chargers and has lost nine straight to Seattle, a streak that props up the favorite's number. The complication is a backup quarterback on the road at State Farm Stadium against a Cardinals team with something to prove. Confirm Darnold is officially out and check Seattle's line.
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